Welcome to the

Puglisi Laboratory
"What is the role of RNA in cellular processes and disease?"

Puglisi Laboratory Overview

Our research group investigates the role of RNA in health and disease. Our goal is to understand the dynamic interplay of RNA conformation, function and mechanism using tools of molecular biophysics, structural biology, physical chemistry and biochemistry. We apply structural methods such as NMR spectroscopy, x-ray crystallography and cryoEM and integrate structural views with real time dynamics at the single-molecule level. Our goal is a unified picture of structure, dynamics and function. A long-term goal is to target processes involving RNA with novel therapeutic strategies.